It's been 20 years since the events of Run Lola Run. Lola's boyfriend is dead now and she has an 18 year old daughter named Lalo. Lalo likes to "Lay low" if you know what I mean. Lola is now retired from running and she owns a restaurant. It's like Rocky Balboa except she's a runner and not a boxer. One night, two punk kids come into the restaurant and rob everybody at gunpoint. They put all the money and shit into a bag and run away. Someone's like "Run, Lola, run! You have to stop them!" so she starts chasing the punks. Punk #1 sees her and is like "Holy shit, it's the famous Running Lola! We better cheese it!" So Lola's chasing them for a few minutes, and she almost catches up to them, but then she has to stop and throw up. She sits down on the curb and tries to catch her breath. She's like 50 years old now so come on, of course she didn't catch them. Then some random kid walks up to her and says "Look at you, Lola. You used to be somethin'. Now you're nothin' but a bum in the streets." Then that kid walks away, never to be seen again.
When Lola returns to the restaurant, everyone's like "So where the fuck is our shit, dawg?" and they're all disappointed in her for not retrieving everything, these selfish fucking assholes. Also one of the people who had their shit stolen is a restaurant critic and because of these events he gives her restaurant only 2 stars out of 5. Lola tries to make up for her customers' losses by giving them all two free cases of her home-made Lola Cola. They all take the Cola, but they're still not happy. And neither is Lola, because she lost a lot of money tonight, but more importantly, she also lost... her dignity, or something. So now Lola's standing in her empty restaurant, and a mysterious stranger enters. He makes her an offer she can't refuse: If she comes out of retirement for one last run, he'll pay her one million dollars. He'll also find the two punks who robbed the restaurant and murder them. So Lola's like "okay cool"
Later, Lola is training for the running. Her daughter Lalo comes to visit her and she's all "What the fuck are you doing, you're too old, you're gonna die, you don't have to prove anything, blah blah blah" and Lola's like "Shut the fuck up" so the Lalo does the opposite of shutting the fuck up: she screams really loudly, and all the in the room glass shatters into a bazillion pieces. Then she runs away, but she didn't inherit her mother's running abilities, so she sucks at running. She trips over on the way out and some random kid (not the same one as before) is like "Have a nice TRIP when you TRIPPED OVER, DAY TRIPPER?!" So then Lola goes over to Lalo and they have a very emotional mother/daughter moment. Lola's like "I gotta do this... there's no other way" and Lalo's like "Cool I hope you win" because she changed her mind since a few seconds ago.
The day of The Big Run. Lola has been training a lot, but everybody's still like "There's no way this old bitch can run". But she sure proves them wrong. She runs faster than the speed of light. She runs around the whole planet twice. Now everyone's like "Holy shit, this old bitch is clearly not human and must be destroyed", so I guess she can't win either way. Then Lola runs into the sky and returns to her home planet. Her half-human daughter is taken prisoner on Earth. The End.